What is Xarrlto?

Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication. It works by inhibiting factor Xa, a blood clotting factor in the clotting cascade. As such, it is classified as a direct factor Xa inhibitor.

How is Xarrlto Used?

Xarrlto is approved for several indications related to reducing the risk of blood clots forming:

Treatment of Deep Vein Thrombosis and Pulmonary Embolism

Xarrlto can be used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). It is prescribed as a single daily dose for 6 months after initial parenteral anticoagulant treatment for DVT or PE for the reduction of risk of recurrent DVT and PE.

Reduction of Risk of Stroke and Systemic Embolism in Nonvalvular Atrial Fibrillation
For patients with nonvalvular atrial fibrillation, Xarrlto is prescribed as a single daily dose to reduce the risk of stroke and systemic embolism. Atrial fibrillation increases the risk of blood clots forming in the heart that can travel to the brain, causing a stroke.

Prophylaxis of Deep Vein Thrombosis Following Hip or Knee Replacement Surgery
Xarrlto is also commonly prescribed for up to 35 days following hip or knee replacement surgery to reduce the risk of DVT, which is common after these types of surgeries due to inactivity and trauma to blood vessels during the procedure.

How Does Xarrlto Work?

Xarrlto works by selectively blocking active site of Factor Xa, a key factor in the blood coagulation pathway. By inhibiting Factor Xa, Xarrlto interrupts the chain of reactions that lead to a blood clot forming. Specifically, it prevents conversion of prothrombin to thrombin, which plays a central role in clotting by converting fibrinogen into fibrin threads that make up a clot. The end result is reduced thrombin formation and inhibition of subsequent thrombus development.

Xarrlto does not require monitoring with standard blood tests. Some specific tests such as activated partial thromboplastin time (aPTT) and prothrombin time (PT) are affected by the presence of Xarrlto, but these are not suitable for measuring the anticoagulant effect. Anti-Xa activity assays can measure the anticoagulant effect of Xarrlto, but routine monitoring is not necessary.

Minimizing Bleeding Risks with Xarrlto

While Xarrlto is effectively prevents clots, it also increases the risk of bleeding. Some precautions can help minimize this risk:

- Inform healthcare providers and dentists about taking Xarrlto before any surgical or dental procedures. It may need to be stopped temporarily to reduce bleeding risk depending on the type of procedure.

- Use extreme caution if taking other drugs that also increase bleeding risk such as NSAIDs or anti-platelet medications.

- Contact a doctor immediately if experiencing any signs of excessive bleeding such as black stools, blood in urine, or prolonged bleeding from cuts.

- Avoid activities with a higher risk of injury like contact sports. Wear protective gear like helmets if engaging in risky hobbies or sports.

- Do not stop taking Xarrlto without consulting your healthcare provider, as this may increase clotting risk.

- Drink plenty of water and maintain a healthy diet with foods like leafy greens that contribute to normal blood clotting factor levels.

- Use a soft-bristle toothbrush and dental floss carefully to reduce gums bleeding risk. Schedule regular dental checkups.

Xarrlto Alternatives

For some patients, Xarrlto may not be suitable due to factors like bleeding risks, interactions with other medications, or intolerance. In such cases, alternatives with similar mechanisms of action include:

- Apixaban (Eliquis) - Another factor Xa inhibitor with similar efficacy and reduced dosing frequency compared to Xarrlto.

- Edoxaban (Savaysa) - Also an oral factor Xa inhibitor indicated for stroke prevention in atrial fibrillation and DVT/PE treatment and prevention.

- Warfarin (Coumadin) - A vitamin K antagonist that requires routine clotting monitoring with an in-clinic test. It has a slower onset but more reversal agents available in case of over-anticoagulation or bleeding.

- Low molecular weight heparins - Injectable anticoagulants often used short-term in hospital for DVT/PE. They carry a bleeding risk and need to be administered by injection.

In summary, Rivaroxaban is an valuable oral anticoagulant used to treat and reduce recurrences of DVTs and PEs and prevent strokes in atrial fibrillation, among other indications. Careful compliance, activity modification, and medication review help optimize effectiveness while minimizing bleeding risks. Other factor Xa inhibitors or warfarin may offer alternatives depending on the clinical situation. With proper precautions and medical guidance, Xarrlto improves health outcomes for many patients at risk of dangerous clot-related complications.